Page 7 - QB-0011-ClinicalTrialSynopsis

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Groton Maze Learning Figure 3: PFeigrcuerent3a:gPeeCrcheanntaggeeoCf GhaMnLg(eADo8f G0-M1)L (AD8 0-1)Percentage Change
Figure 3 shows the average percentage change 0
in GML scores from Baseline to each visit in -3.04
participants with AD8 scores of 0-1. As compared
to Baseline, both groups showed statistically -5
significant reductions in total errors (Experimental -7.14
p<0.0001, Control p=0.003). There was a trend
towards significance in comparing the results -10 -11.44
from the Experimental group to the Control
group (p=0.103). -15 -15.30 -16.88
-20 -17.59
Figure 4 shows the average percentage change -17.52
in GML scores from Baseline to each visit in par- 08 30 60
ticipants with AD8 scores of 0-2. The Experimental Day -22.66
group demonstrated a 20.70% reduction in the 90
number of moves required to traverse a 10x10
maze, while the Control group exhibited a 17.14% Group Control Treat
reduction. As compared to Baseline, both groups
experienced a statistically significant reduction Figure 4: PFeigrcuerent4a:gPeeCrcheanntaggeeoCf GhaMnLg(eADof8G0-M2)L (AD8 0-2)
in the number of moves required (Experimental 0
p<0.0001, Control p=0.0002). The Experimental
group’s results were statistically significant as Percentage Change -5 -6.68 -7.95 -9.24
compared to the Control group (p=0.0400).
-10 -18.11 -18.02 -17.14
Groton Maze Recall -12.48 30 60 -20.70
Figure 5 shows the average percentage change
in GMR scores from Baseline to each visit in par- -15 Day 90
ticipants with AD8 scores of 0-1. The Experimental
group required 30.89% fewer moves to complete -20
the maze between Days 0 and 90. The Control 08
group experienced a 4.33% reduction. Compared
to Baseline, a statistically significant change was Group Control Treat
observed in the Experimental group (p=0.000), but
not the Control group (p=0.296). The Experimental Figure 5: PFeigrcuerent5a:gPeeCrcheanntaggeeoCf GhaMnRg(eAoDf8G0M-1R) (AD8 0-1)Percentage Change
group’s results were statistically significant 10 8.14
compared to the Control group (p=0.011).
5.76
0
-4.33
-10 -13.59 -15.96
-20 -18.55 -16.52
-30 8 30 -30.89
0 Day 60 90
Group Control Treat
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