Page 7 - QB-0011-ClinicalTrialSynopsis
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Groton Maze Learning                                  Figure 3: PFeigrcuerent3a:gPeeCrcheanntaggeeoCf GhaMnLg(eADo8f G0-M1)L (AD8 0-1)Percentage Change
Figure 3 shows the average percentage change                  0
in GML scores from Baseline to each visit in                                -3.04
participants with AD8 scores of 0-1. As compared
to Baseline, both groups showed statistically                -5
significant reductions in total errors (Experimental                                            -7.14
p<0.0001, Control p=0.003). There was a trend
towards significance in comparing the results                            -10 -11.44
from the Experimental group to the Control
group (p=0.103).                                                         -15                            -15.30           -16.88
                                                                         -20                                      -17.59
Figure 4 shows the average percentage change                                                                                          -17.52
in GML scores from Baseline to each visit in par-                               08               30 60
ticipants with AD8 scores of 0-2. The Experimental                                                           Day                     -22.66
group demonstrated a 20.70% reduction in the                                                                                                 90
number of moves required to traverse a 10x10
maze, while the Control group exhibited a 17.14%                                      Group                     Control  Treat
reduction. As compared to Baseline, both groups
experienced a statistically significant reduction     Figure 4: PFeigrcuerent4a:gPeeCrcheanntaggeeoCf GhaMnLg(eADof8G0-M2)L (AD8 0-2)
in the number of moves required (Experimental                 0
p<0.0001, Control p=0.0002). The Experimental
group’s results were statistically significant as     Percentage Change   -5 -6.68                -7.95                   -9.24
compared to the Control group (p=0.0400).
                                                                         -10                      -18.11                  -18.02     -17.14
Groton Maze Recall                                                                       -12.48  30                      60          -20.70
Figure 5 shows the average percentage change
in GMR scores from Baseline to each visit in par-                        -15                                 Day                             90
ticipants with AD8 scores of 0-1. The Experimental
group required 30.89% fewer moves to complete                            -20
the maze between Days 0 and 90. The Control                                     08
group experienced a 4.33% reduction. Compared
to Baseline, a statistically significant change was                                              Group          Control  Treat
observed in the Experimental group (p=0.000), but
not the Control group (p=0.296). The Experimental     Figure 5: PFeigrcuerent5a:gPeeCrcheanntaggeeoCf GhaMnRg(eAoDf8G0M-1R) (AD8 0-1)Percentage Change
group’s results were statistically significant               10 8.14
compared to the Control group (p=0.011).
                                                                           5.76

                                                              0
                                                                                                                                              -4.33

                                                                         -10                     -13.59                  -15.96
                                                                         -20 -18.55                                          -16.52

                                                                         -30       8             30                                     -30.89
                                                                                0                          Day           60 90

                                                                                      Group             Control            Treat

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